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Table 2 Synovial fluid concentrations of the biological markers in patients with OA or RA and in asymptomatic organ donorsa

From: The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors

     P values
Marker Donor (n = 20) OA (n = 45) RA (n = 22) OA vs. donor RA vs. donor OA vs. RA
IL-6, pg/mL 86.97 (82.0) 119.4 (193.2) 354.7 (1851.6) 0.4 0.0011 0.0026
IL-8, pg/mL 451 (170.7) 429 (87.3) 583.6 (1086.4) 0.0809 0.016 <0.0001
IL-11, pg/mL 211.6 (40.8) 296.2 (257.2) 217.5 (178) 0.0067 0.4557 0.2393
IL-1, pg/mL 9.08 (1.6) 7.76 (2.6) 9.26 (11.1) 0.02 0.9318 0.0497
OP-1, ng/mL 54.49 (29.3) 81.79 (116.0) 167.1 (194.8) <0.0001 <0.0001 0.0013
LIF, pg/mL 228.5 (131.6) 107.5 (136.9) 128.4 (222.7) 0.0063 0.139 0.1991
Osteo, ng/mL 2.58 (6.6) 2.515 (4.9) 1.99 (3.9) 0.7437 0.893 0.5384
COMP, U/L 413.2 (339.9) 490.2 (207.5) 507.3 (352.9) 0.4652 0.3102 0.3865
  1. aOA, osteoarthritis; RA, rheumatoid arthritis; IL, interleukin; OP-1, osteogenic protein 1; LIF, leukemia-inhibitory factor; Osteo, osteocalcin; COMP, cartilage oligomeric protein. Absolute values of biomarkers detected in synovial fluid of patients with osteoarthritis, rheumatoid arthritis and asymptomatic organ donors. P values were calculated by using an unpaired, two-tailed Mann-Whitney t-test with 95% confidence interval. Values are expressed as medians (interquartile ranges).