Skip to main content

Advertisement

Table 1 CIA susceptibility in Cystatin C-deficient mice compared to heterozygous and wild type littermates

From: Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development

Genotype Arthritis incidence # , number with/number without (%) Maximum score, mean ± SEM Day of onset , mean ± SEM Disease Duration mean ± SEM Recovery § rate: number recovered/number active arthritis (%) Area under curve
Cystatin C -/- 25/8 (75*) 6.917 ± 0.72 44.57** ± 2.88 67.96* ± 5.29 4/21 (16*) 259.9
Cystatin C +/- 23/12 (65) 7.955 ± 0.83 47.91** ± 4.23 54.41 ± 5.90 9/14 (39) 230.8
Cystatin C +/+ 12/13 (48) 6.500 ± 1.15 69.67 ± 7.78 38.08 ± 8.06 6/6 (50) 156.4
  1. # Cumulative incidence, that is, all mice that have presented with arthritis. Chi-square test was used for determining statistical significance; † Mann Whitney test was used for determining statistical significance; § Percent recovery was calculated by: (number of mice that had presented arthritis but did not have active arthritis at Day 115 divided by the total number of mice that had presented arthritis during the 115-day period) multiplied by 100. Chi-square test was used for determining statistical significance; * P-value less than 0.05; ** P-value less than 0.01