Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development

Table 1 CIA susceptibility in Cystatin C-deficient mice compared to heterozygous and wild type littermates

Genotype	Arthritis incidence ^# , number with/number without (%)	Maximum score, mean ± SEM	Day of onset ^† , mean ± SEM	Disease Duration ^† mean ± SEM	Recovery ^§ rate: number recovered/number active arthritis (%)	Area under curve
Cystatin C -/-	25/8 (75*)	6.917 ± 0.72	44.57** ± 2.88	67.96* ± 5.29	4/21 (16*)	259.9
Cystatin C +/-	23/12 (65)	7.955 ± 0.83	47.91** ± 4.23	54.41 ± 5.90	9/14 (39)	230.8
Cystatin C +/+	12/13 (48)	6.500 ± 1.15	69.67 ± 7.78	38.08 ± 8.06	6/6 (50)	156.4

# Cumulative incidence, that is, all mice that have presented with arthritis. Chi-square test was used for determining statistical significance; † Mann Whitney test was used for determining statistical significance; § Percent recovery was calculated by: (number of mice that had presented arthritis but did not have active arthritis at Day 115 divided by the total number of mice that had presented arthritis during the 115-day period) multiplied by 100. Chi-square test was used for determining statistical significance; * P-value less than 0.05; ** P-value less than 0.01

ISSN: 1478-6362