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Table 2 Suggested main subgroups of OA in clinical research

From: Osteoarthritis subpopulations and implications for clinical trial design

OA phenotypes
   Joint site/joint compartment
   Localized or generalized osteoarthritis
   Structural osteoarthritis subtypes
   Pain phenotypes
Structural or symptomatic stage
   Pain severity
   Restricted motion
   Radiographic severity
   Effusion/synovitis
   Bone marrow lesions
Co-morbidity
   Obesity
   Cardiovascular disease
   Chronic obstructive pulmonary disease
   Depression
Personal factors
   Gender
   Age
   Treatment preference
   Psychosocial factors