Table 2 Suggested main subgroups of OA in clinical research
From: Osteoarthritis subpopulations and implications for clinical trial design
| OA phenotypes |
| Joint site/joint compartment |
| Localized or generalized osteoarthritis |
| Structural osteoarthritis subtypes |
| Pain phenotypes |
| Structural or symptomatic stage |
| Pain severity |
| Restricted motion |
| Radiographic severity |
| Effusion/synovitis |
| Bone marrow lesions |
| Co-morbidity |
| Obesity |
| Cardiovascular disease |
| Chronic obstructive pulmonary disease |
| Depression |
| Personal factors |
| Gender |
| Age |
| Treatment preference |
| Psychosocial factors |