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Table 2 Suggested main subgroups of OA in clinical research

From: Osteoarthritis subpopulations and implications for clinical trial design

OA phenotypes
   Joint site/joint compartment
   Localized or generalized osteoarthritis
   Structural osteoarthritis subtypes
   Pain phenotypes
Structural or symptomatic stage
   Pain severity
   Restricted motion
   Radiographic severity
   Bone marrow lesions
   Cardiovascular disease
   Chronic obstructive pulmonary disease
Personal factors
   Treatment preference
   Psychosocial factors