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Table 2 Suggested main subgroups of OA in clinical research

From: Osteoarthritis subpopulations and implications for clinical trial design

OA phenotypes

   Joint site/joint compartment

   Localized or generalized osteoarthritis

   Structural osteoarthritis subtypes

   Pain phenotypes

Structural or symptomatic stage

   Pain severity

   Restricted motion

   Radiographic severity

   Effusion/synovitis

   Bone marrow lesions

Co-morbidity

   Obesity

   Cardiovascular disease

   Chronic obstructive pulmonary disease

   Depression

Personal factors

   Gender

   Age

   Treatment preference

   Psychosocial factors