From: Osteoarthritis subpopulations and implications for clinical trial design
OA phenotypes |
   Joint site/joint compartment |
   Localized or generalized osteoarthritis |
   Structural osteoarthritis subtypes |
   Pain phenotypes |
Structural or symptomatic stage |
   Pain severity |
   Restricted motion |
   Radiographic severity |
   Effusion/synovitis |
   Bone marrow lesions |
Co-morbidity |
   Obesity |
   Cardiovascular disease |
   Chronic obstructive pulmonary disease |
   Depression |
Personal factors |
   Gender |
   Age |
   Treatment preference |
   Psychosocial factors |