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Table 6 Changes in proteases and their inhibitors

From: Regulation of chondrocyte gene expression by osteogenic protein-1

  rhOP-1 vs Cntr rhOP-1AS vs Cntr  
  fold change fold change Accession no.
Bcl-2 2.45↓   [GenBank:NM_001191]
Caspase 4, apoptosis-related cysteine protease 2.11↓ 1.59↓ [GenBank:NM_001225]
Programmed cell death 8 (apoptosis-inducing factor) 1.70↓   [GenBank:NM_004208]
Calpain 9 1.55↓   [GenBank:NM_006615]
Caspase 6   2.18↓ [GenBank:NM_001226]
Caspase 8   1.82↓ [GenBank:NM_001228]
Caspase 2   1.50↑ [GenBank:NM_001224]
MMPs and inhibitors    
TIMP-3 2.06↓   [GenBank:NM_000362]
MMP-14 1.55↓   [GenBank:NM_004995]
MMP-2   2.31↓ [GenBank:NM_004530]
TIMP-4   1.69↓ [GenBank:NM_003256]
MMP-9   1.50↓ [GenBank:NM_004994]
ADAM and ADAMTS    
ADAM-19 1.83↓   [GenBank:NM_023038]
ADAM-15 1.51↓   [GenBank:NM_003815]
ADAMTS-12 1.88↑ 2.03↑ [GenBank:NM_030955]
ADAMTS-7 1.58↑   [GenBank:NM_014272]
ADAM-10   2.34↓ [GenBank:NM_001110]
ADAM-28   1.63↓ [GenBank:NM_014265]
ADAM-9   1.61↓ [GenBank:NM_003816]
ADAM-7   1.56↑ [GenBank:NM_003817]
Cathepsins    
Cathepsin B   2.14↓ [GenBank:NM_001908]
Cathepsin C   1.75↓ [GenBank:NM_001814]
Cathepsin S   1.75↓ [GenBank:NM_004079]
Other proteases    
Transglutaminase 2 2.10↓   [GenBank:NM_004613]
Plasminogen activator-urokinase 1.57↓   [GenBank:NM_002658]
Tissue Plasminogen Activator 1.56↑   [GenBank:NM_000930]