Regulation of chondrocyte gene expression by osteogenic protein-1

Table 6 Changes in proteases and their inhibitors

	rhOP-1 vs Cntr	rhOP-1AS vs Cntr
	fold change	fold change	Accession no.
Bcl-2	2.45↓		[GenBank:NM_001191]
Caspase 4, apoptosis-related cysteine protease	2.11↓	1.59↓	[GenBank:NM_001225]
Programmed cell death 8 (apoptosis-inducing factor)	1.70↓		[GenBank:NM_004208]
Calpain 9	1.55↓		[GenBank:NM_006615]
Caspase 6		2.18↓	[GenBank:NM_001226]
Caspase 8		1.82↓	[GenBank:NM_001228]
Caspase 2		1.50↑	[GenBank:NM_001224]
*MMPs and inhibitors*
TIMP-3	2.06↓		[GenBank:NM_000362]
MMP-14	1.55↓		[GenBank:NM_004995]
MMP-2		2.31↓	[GenBank:NM_004530]
TIMP-4		1.69↓	[GenBank:NM_003256]
MMP-9		1.50↓	[GenBank:NM_004994]
*ADAM and ADAMTS*
ADAM-19	1.83↓		[GenBank:NM_023038]
ADAM-15	1.51↓		[GenBank:NM_003815]
ADAMTS-12	1.88↑	2.03↑	[GenBank:NM_030955]
ADAMTS-7	1.58↑		[GenBank:NM_014272]
ADAM-10		2.34↓	[GenBank:NM_001110]
ADAM-28		1.63↓	[GenBank:NM_014265]
ADAM-9		1.61↓	[GenBank:NM_003816]
ADAM-7		1.56↑	[GenBank:NM_003817]
*Cathepsins*
Cathepsin B		2.14↓	[GenBank:NM_001908]
Cathepsin C		1.75↓	[GenBank:NM_001814]
Cathepsin S		1.75↓	[GenBank:NM_004079]
*Other proteases*
Transglutaminase 2	2.10↓		[GenBank:NM_004613]
Plasminogen activator-urokinase	1.57↓		[GenBank:NM_002658]
Tissue Plasminogen Activator	1.56↑		[GenBank:NM_000930]

ISSN: 1478-6362