Table 8 Association between OP-1 and other growth factors including igf-1, insulin, and tyrosine-kinase signaling
From: Regulation of chondrocyte gene expression by osteogenic protein-1
| Â | rhOP-1 vs Cntr | OP-1AS vs Cntr |
|---|---|---|
| Â | fold change | fold change |
IGF-BP1 | 2.17↓ |  |
Nerve growth factor-β | 1.93↓ |  |
VEGF-β | 1.62↓ | 1.50↓ |
Endothelial cell growth factor 1 (platelet-derived) | 1.56↓ |  |
VEGF | 1.52↓ |  |
Capillary morphogenesis protein 1 | 1.52↓ |  |
FGF-7 |  | 2.87↓ |
FGF-R2 | 1.69↑ | 2.83↓ |
IGF-BP5 |  | 1.90↓ |
FGF-R3 | 1.87↑ | 1.80↓ |
IGF-1R |  | 1.73↓ |
PDGF-Rα | 1.62↑ | 1.70↓ |
PDGF-Rβ |  | 1.68↓ |
IGF-BP7 |  | 1.58↓ |
IRS2 (insulin receptor substrate 2) | 2.10↓ | 1.70↑ |
DPYSL2 (dihydropyrimidinase-like 2) | 1.60↑ | 1.60↓ |
MET (hepatocyte growth factor receptor) | 1.70↓ | 1.60↑ |
SPRY2: sprouty homolog 2 (Drosophila) | 1.60↓ | 1.60↑ |
SORBS1: sorbin and SH3 domain containing 1 | 1.70↑ | 1.50↓ |
PIK3R1 (Phosphoinositide-3-kinase, regulatory subunit 1) | 1.72↑ |  |
MAP2K2 (mitogen-activated protein kinase kinase 2) | 1.61↑ |  |
PDE3B (phosphodiesterase 3B, cGMP-inhibited) | 2.00↑ |  |
SOCS3 (suppressor of cytokine signaling 3) | 1.79↑ |  |