Skip to main content

Table 8 Association between OP-1 and other growth factors including igf-1, insulin, and tyrosine-kinase signaling

From: Regulation of chondrocyte gene expression by osteogenic protein-1

  rhOP-1 vs Cntr OP-1AS vs Cntr
  fold change fold change
IGF-BP1 2.17↓  
Nerve growth factor-β 1.93↓  
VEGF-β 1.62↓ 1.50↓
Endothelial cell growth factor 1 (platelet-derived) 1.56↓  
VEGF 1.52↓  
Capillary morphogenesis protein 1 1.52↓  
FGF-7   2.87↓
FGF-R2 1.69↑ 2.83↓
IGF-BP5   1.90↓
FGF-R3 1.87↑ 1.80↓
IGF-1R   1.73↓
PDGF-Rα 1.62↑ 1.70↓
PDGF-Rβ   1.68↓
IGF-BP7   1.58↓
IRS2 (insulin receptor substrate 2) 2.10↓ 1.70↑
DPYSL2 (dihydropyrimidinase-like 2) 1.60↑ 1.60↓
MET (hepatocyte growth factor receptor) 1.70↓ 1.60↑
SPRY2: sprouty homolog 2 (Drosophila) 1.60↓ 1.60↑
SORBS1: sorbin and SH3 domain containing 1 1.70↑ 1.50↓
PIK3R1 (Phosphoinositide-3-kinase, regulatory subunit 1) 1.72↑  
MAP2K2 (mitogen-activated protein kinase kinase 2) 1.61↑  
PDE3B (phosphodiesterase 3B, cGMP-inhibited) 2.00↑  
SOCS3 (suppressor of cytokine signaling 3) 1.79↑