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Table 1 Selected genes for validation by qPCR

From: Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Gene symbol

Fold-change (AS/Cont)

Parametric P-value

CX3CR1

0.58

3.45E-04

DGKQ

0.62

1.45E-05

SPOCK2

0.65

3.07E-04

SBK1

0.66

1.69E-04

GZMM

0.67

3.39E-04

CDC25B

0.67

2.00E-04

CLSTN1

0.68

4.53E-04

ITGB7

0.68

5.63E-04

PTPN1

0.69

1.50E-06

EP300

0.70

1.26E-04

DOCK10

0.70

1.73E-04

MAPK8IP3

0.70

3.37E-04

BCL11B

0.70

5.88E-04

DNMT1

0.71

6.46E-05

XPC

0.71

5.10E-06

PPP2R1A

0.71

1.73E-04

IL27RA

0.72

4.40E-06

MCM3

0.73

4.24E-04

SYF2

1.34

5.94E-04

PPP2R3C

1.36

1.07E-03

NGFRAP1

1.37

1.87E-04

ZMAT2

1.38

1.58E-04

MYL6

1.41

7.94E-05

S100A8

1.43

6.09E-04

GMFG

1.43

3.91E-05

VAMP5

1.44

4.21E-04

CKLF

1.46

4.30E-04

SHFM1

1.47

8.62E-04

ATG3

1.49

6.10E-04

MRPS18C

1.49

5.71E-04

CLEC4D

1.52

3.47E-04

UBL5

1.52

8.93E-05

AIF1

1.52

5.19E-04

PDCD10

1.54

2.45E-03

NDUFS4

1.54

5.93E-04

SF3B14

1.54

2.39E-04

HMGB2

1.57

3.41E-04

UQCRB

1.63

2.33E-04

TXN

1.68

4.39E-05

CMTM2

1.74

4.78E-04

CIP29

1.75

1.38E-04

CHMP5

1.78

6.80E-04

PSMA4

1.80

8.45E-05

NDUFB3

1.88

1.25E-04

LSM3

1.99

6.72E-04

GNG11

2.15

1.41E-04

CCDC72

2.21

9.64E-05

  1. Genes (n = 47) for validation by qPCR were selected from the 648 probes significantly differentially expressed in microarrays based upon their P-value, fold-change and biological relevance. AS, Ankylosing spondylitis; qPCR, quantitative polymerase chain reaction.