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Table 3 Extrinsic factor-induced models of Sjögren's syndrome

From: Sjögren's syndrome: studying the disease in mice

Strain Extrinsic factor SS-like disease manifestations Remarks Reference
BALB/c Ro amino acids 480 to 494 SG infl., ↓ SG function, anti-Ro and anti-La Low disease penetrance rate [136]
  Ro amino acids 274 to 290 SG infl., ↓ SG function, anti-Ro and anti-La Low disease penetrance rate [136]
C57BL/6-Rag1-/- Six peptides from M3R SG and LG infl., ↓ SG function Splenocytes from vaccinated M3r-/- mice [140]
PL/J CAII SG infl. Inflammatory lesions in multiple organs [142]
C57BL/6-gld//gld MCMV SG infl., anti-Ro and anti-La Incomplete clearance of the MCMV [144]
  1. Selection of murine strains in which Sjögren's syndrome (SS)-like disease manifestations develop after the administration of specific extrinsic factors. ↑, increased; ↓, decreased; CAII, carbonic anhydrase II; infl., inflammation; LG, lacrimal gland; M3R, muscarinic acetylcholine type-3 receptor; MCMV, murine cytomegalovirus; SG, salivary gland.