Sjögren's syndrome: studying the disease in mice

Table 3 Extrinsic factor-induced models of Sjögren's syndrome

Strain	Extrinsic factor	SS-like disease manifestations	Remarks	Reference
BALB/c	Ro amino acids 480 to 494	SG infl., ↓ SG function, anti-Ro and anti-La	Low disease penetrance rate	[136]
	Ro amino acids 274 to 290	SG infl., ↓ SG function, anti-Ro and anti-La	Low disease penetrance rate	[136]
C57BL/6-Rag1^-/-	Six peptides from M3R	SG and LG infl., ↓ SG function	Splenocytes from vaccinated M3r^-/- mice	[140]
PL/J	CAII	SG infl.	Inflammatory lesions in multiple organs	[142]
C57BL/6-gld//gld	MCMV	SG infl., anti-Ro and anti-La	Incomplete clearance of the MCMV	[144]

Selection of murine strains in which Sjögren's syndrome (SS)-like disease manifestations develop after the administration of specific extrinsic factors. ↑, increased; ↓, decreased; CAII, carbonic anhydrase II; infl., inflammation; LG, lacrimal gland; M3R, muscarinic acetylcholine type-3 receptor; MCMV, murine cytomegalovirus; SG, salivary gland.

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