Figure 1

Network pathway analysis of upregulated genes in the gene category regulation of apoptosis. (a) Network 1 and (b) Network 2 constructed by 42 upregulated genes. (c) Network graphical representation. Genes or gene products are represented as individual nodes whose shapes represent the functional class of the gene products. The biological relationship between the two nodes is represented as an edge (line). All edges are supported by at least one reference from the literature stored in the Ingenuity Pathways Knowledge Base (IPKB). Genes with colored nodes were found over-represented in the gene category regulation of apoptosis. Genes with uncolored nodes were not found over-represented, but were depicted by computationally generated networks on the basis of evidence stored in the IPKB, indicating strong biologic relevance to that network.