Table 1 Deviated GO Biological Process gene categories of upregulated genes in peripheral blood of SLE patients
Gene category | List hits (n= 1,759) | Population hits (n= 13,802) | EASE score (<0.01) |
|---|---|---|---|
Response to external stimulus | 265 | 1,539 | 6.56 × 10-8 |
Response to biotic stimulus | 192 | 963 | 7.36 × 10-11 |
Defense response | 176 | 887 | 7.69 × 10-10 |
Immune response | 159 | 792 | 2.45 × 10-9 |
Response to stress | 147 | 872 | 2.39 × 10-4 |
Response to pest/pathogen/parasite | 97 | 501 | 2.09 × 10-5 |
Response to wounding | 59 | 303 | 8.83 × 10-4 |
Inflammatory response | 48 | 187 | 2.68 × 10-6 |
Cell growth and/or maintenance | 572 | 4,092 | 3.09 × 10-3 |
Modification-dependent protein catabolism | 28 | 123 | 2.99 × 10-3 |
Ubiquitin-dependent protein catabolism | 27 | 122 | 5.34 × 10-3 |
Cell motility | 62 | 342 | 3.78 × 10-3 |
Regulation of apoptosis | 42 | 214 | 4.60 × 10-3 |
Induction of apoptosis by extracellular signals | 11 | 35 | 9.91 × 10-3 |