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Table 1 Histopathology of liver involvement in systemic rheumatic diseases

From: Liver involvement in subjects with rheumatic disease

Histological definition Features
Chronic active hepatitis Piecemeal necrosis with mononuclear cell infiltrate
Chronic persistent hepatitis Chronic inflammatory infiltration of the portal tract with preserved lobular architecture and without portal fibrosis
Cirrhosis Diffuse liver degeneration characterized by fibrous tissue and regenerative nodules
Fibrosis Abnormal production of fibrous tissue in response to liver injury
Steatosis Abnormal retention of lipids within hepatocytes
Cholangitis Inflammation of bile ducts
Reactive hepatitis Aspecific and mild inflammatory cell infiltrate of portal spaces
Nodular regenerative hyperplasia Diffuse nodularity of the liver without fibrosis
Granulomas Aggregate of epithelioid cells surrounded by lymphocytes
Idiopathic portal hypertension Increased blood pressure in the veins of the portal system not due to liver diseases
Arteritis Vessel wall inflammation
Giant cell hepatitis Presence throughout the liver of enlarged multinucleated hepatocytes with abundant cytoplasm
Massive hepatic necrosis Diffuse hepatocyte necrosis