Skip to main content

Table 2 Rheumatoid arthritis risk associated with MBL-high genotype in the whole EIRA study group and stratified for serology and smoking status

From: Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers

  Whole group Never smokers Ever smokers
  Number of cases/controls OR (95% CI) a OR (95% CI) a OR (95% CI) a
Whole group 1,666/920 1.03 (0.87-1.21) 1.39 (1.04-1.85) 0.83 (0.67-1.04)
Stratification by serological status   
Seronegative     
   RF- 476/920 1.20 (0.96-1.51) 1.82 (1.24-2.69) 0.96 (0.73-1.28)
   ACPA- 585/920 1.03 (0.83-1.27) 1.42 (0.98-2.05) 0.77 (0.58-1.04)
   RF-/ACPA- 361/920 1.14 (0.89-1.47) 1.67 (1.10-2.55) 0.80 (0.56-1.13)
RF-/ACPA+b 105/920 1.54 (0.99-2.38) 3.07 (1.37-6.89) 1.06 (0.57-1.99)
Seropositive     
   RF+ 925/920 1.00 (0.83-1.20) 1.26 (0.89-1.78) 0.86 (0.68-1.10)
   ACPA+ 916/920 1.08 (0.89-1.30) 1.55 (1.08-2.23) 0.88 (0.69-1.13)
   RF+/ACPA-c 172/920 0.83 (0.59-1.17) 0.96 (0.53-1.74) 0.74 (0.47-1.17)
   RF+/ACPA+ 744/920 1.06 (0.87-1.29) 1.42 (0.97-2.10) 0.90 (0.70-1.16)
  1. aRisk was calculated as odds ratios (ORs) with 95% confidence intervals (CIs) adjusted for age, sex, and geographic location by using logistic regression. bIn the ACPA+ group, 20% of never smokers and 10% of smokers were RF-: OR 2.07 (1.36 to 3.14), P = 0.0005. cIn the RF+ group, 24% of never smokers and 17% of smokers were ACPA-: OR 1.58 (1.11 to 2.25), P = 0.01. ACPA, anti-citrullinated protein antibody; EIRA, Epidemiological Investigation of Rheumatoid Arthritis; MBL, mannan-binding lectin; RF, rheumatoid factor.