TY - JOUR AU - Kapinas, Kristina AU - Delany, Anne M. PY - 2011 DA - 2011/05/27 TI - MicroRNA biogenesis and regulation of bone remodeling JO - Arthritis Research & Therapy SP - 220 VL - 13 IS - 3 AB - MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work on the role of miRNAs, including the miR-29 family, in bone remodeling. These studies represent the first steps in demonstrating the importance of miRNAs in the control of osteoblast and osteoclast differentiation and function. An in-depth understanding of the roles of these regulatory RNAs in the skeleton will be critical for the development of new therapeutics aimed at treating bone loss and perhaps facilitating fracture repair. SN - 1478-6354 UR - https://doi.org/10.1186/ar3325 DO - 10.1186/ar3325 ID - Kapinas2011 ER -