Recent advances in the immunogenetics of idiopathic inflammatory myopathy

Table 1 HLA associations in ethnically different myositis populations

Population	Ethnicity	Allele	Reference
IIM	Caucasian	HLA common ancestral Haplotype (A1;B8;DR3)	[5, 8–15]
IIM	Caucasian	EYSTS, DRB1 HVR motif	[10, 12, 14]
PM	Caucasian	Cw*0701
		DRB1*0401 (protective)	[12]
		DQA1*0201 (protective)
PM	Caucasian	DRB1*07 (protective)	[13]
		DQA1*02 (protective)
PM	Caucasian	DPB1*0101	[16]
DM	Caucasian	A68 DQA101 (protective)	[12]
Familial IIM	Caucasian	DQA1 homozygosity	[5]
JDM	Caucasian	DMA*0103	[17]
IIM	African-American	DRB1*14 (protective)	[18]
IIM	African-American	B7; DRw6	[19]
DM/JDM	African-American	DRB1*0301	[18]
JDM	African-American	DQA1*0501	[20]
JDM	Hispanic	DQA1*0501	[20]
JDM	Hispanic	DR3	[21]
PM	Japanese	DRB1*0803	[22]

All listed risk/protective factors are risk alleles/haplotypes unless stated otherwise. Data are presented only if results remain significant after corrections for multiple comparisons are applied to probability values. DM, dermatomyositis; IIM, idiopathic inflammatory myopathy; JDM, juvenile dermatomyositis; PM, polymyositis.

ISSN: 1478-6362