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Table 1 CAIA model joint inflammation histopathology scoresa

From: A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

Group Proteoglycan loss Matrix erosion Subchondral osteolysis Osteoproliferation Synovial proliferation Pannus formation Inflammation degree
Vehicle 1.55 ± 0.07 3.12 ± 0.71 2.50 ± 1.00 1.65 ± 0.47 2.00 ± 0.81 1.12 ± 0.85 1.75 ± 0.95
CEP-33779 10 mg/kg 1.39 ± 0.38 3.40 ± 2.07 2.30 ± 1.30 1.70 ± 1.09 2.40 ± 1.34 1.30 ± 0.97 1.60 ± 1.14
CEP-33779 30 mg/kg 1.12 ± 0.88 0.75 ± 0.95 0.62 ± 0.47* 0.87 ± 0.62 0.25 ± 0.50* 0.00 ± 0.00 0.12 ± 0.25*
CEP-33779 55 mg/kg 2.05 ± 0.07 0.70 ± 0.44* 0.60 ± 0.41** 0.30 ± 0.72* 0.30 ± 0.44* 0.00 ± 0.00* 0.20 ± 0.27*
Dex 1.5 mg/kg 0.98 ± 0.44 1.00 ± 0.79 0.50 ± 0.35** 0.70 ± 0.44 0.40 ± 0.54* 0.10 ± 0.22 0.30 ± 0.44*
Compared to vehicle *P < 0.05 **P < 0.01 ***P < 0.001     
  1. aCAIA, collagen-antibody induced arthritis; Dex, dexamethasone. Hematoxylin and eosin- and Safranin O-stained, paraffin wax-embedded carpus and tarsus sections were scored by a board-certified independent pathologist for the criteria described in Materials and methods. Values are means ± SD for the tarsus only. P values show significance as compared to vehicle group; n = 5 mice per group. Statistical test used was two-way analysis of variance (ANOVA). *P < 0.05. **P < 0.01. ***P < 0.001.