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Table 2 CIA model joint inflammation histopathology scoresa

From: A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

Group Proteoglycan loss Matrix erosion Subchondral osteolysis Osteoproliferation Synovial proliferation Pannus formation Inflammation degree
Vehicle 3.00 ± 0.00 3.67 ± 1.52 2.50 ± 0.50 2.66 ± 0.57 2.66 ± 0.57 1.66 ± 0.57 2.83 ± 0.28
Compound A 30 mg/kg 2.50 ± 0.57 4.62 ± 0.75 2.75 ± 0.50 2.50 ± 0.40 2.75 ± 0.50 2.37 ± 0.94 2.12 ± 0.25
Compound A 55 mg/kg 1.83 ± 0.76 2.83 ± 1.60 1.33 ± 1.04 1.83 ± 1.15 1.00 ± 0.86 0.83 ± 0.76 0.66 ± 0.57*
Compound A 100 mg/kg 1.83 ± 0.28 2.33 ± 1.52 1.50 ± 0.50 1.66 ± 0.57 1.50 ± 0.86 0.66 ± 1.15 1.33 ± 0.57**
Dex 1.5 mg/kg 2.25 ± 0.95 3.12 ± 2.09 1.37 ± 0.94 1.50 ± 1.08 1.25 ± 0.86 0.75 ± 0.64 1.00 ± 0.81**
Compared to vehicle *P < 0.05 **P < 0.01 ***P < 0.001     
  1. aCIA, collagen-induced arthritis. Hematoxylin and eosin- and Safranin O-stained, paraffin wax-embedded carpus and tarsus sections were scored by a board-certified independent pathologist for the criteria described in Materials and methods. Values are means ± SD for the tarsus only. P values show significance compared to vehicle group; n = 5 mice per group. Statistical test used was two-way ANOVA. *P < 0.05. **P < 0.01. ***P < 0.001.