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Table 2 CIA model joint inflammation histopathology scoresa

From: A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

Group

Proteoglycan loss

Matrix erosion

Subchondral osteolysis

Osteoproliferation

Synovial proliferation

Pannus formation

Inflammation degree

Vehicle

3.00 ± 0.00

3.67 ± 1.52

2.50 ± 0.50

2.66 ± 0.57

2.66 ± 0.57

1.66 ± 0.57

2.83 ± 0.28

Compound A 30 mg/kg

2.50 ± 0.57

4.62 ± 0.75

2.75 ± 0.50

2.50 ± 0.40

2.75 ± 0.50

2.37 ± 0.94

2.12 ± 0.25

Compound A 55 mg/kg

1.83 ± 0.76

2.83 ± 1.60

1.33 ± 1.04

1.83 ± 1.15

1.00 ± 0.86

0.83 ± 0.76

0.66 ± 0.57*

Compound A 100 mg/kg

1.83 ± 0.28

2.33 ± 1.52

1.50 ± 0.50

1.66 ± 0.57

1.50 ± 0.86

0.66 ± 1.15

1.33 ± 0.57**

Dex 1.5 mg/kg

2.25 ± 0.95

3.12 ± 2.09

1.37 ± 0.94

1.50 ± 1.08

1.25 ± 0.86

0.75 ± 0.64

1.00 ± 0.81**

Compared to vehicle

*P < 0.05

**P < 0.01

***P < 0.001

    
  1. aCIA, collagen-induced arthritis. Hematoxylin and eosin- and Safranin O-stained, paraffin wax-embedded carpus and tarsus sections were scored by a board-certified independent pathologist for the criteria described in Materials and methods. Values are means ± SD for the tarsus only. P values show significance compared to vehicle group; n = 5 mice per group. Statistical test used was two-way ANOVA. *P < 0.05. **P < 0.01. ***P < 0.001.