Group | Proteoglycan loss | Matrix erosion | Subchondral osteolysis | Osteoproliferation | Synovial proliferation | Pannus formation | Inflammation degree |
---|---|---|---|---|---|---|---|
Vehicle | 3.00 ± 0.00 | 3.67 ± 1.52 | 2.50 ± 0.50 | 2.66 ± 0.57 | 2.66 ± 0.57 | 1.66 ± 0.57 | 2.83 ± 0.28 |
Compound A 30 mg/kg | 2.50 ± 0.57 | 4.62 ± 0.75 | 2.75 ± 0.50 | 2.50 ± 0.40 | 2.75 ± 0.50 | 2.37 ± 0.94 | 2.12 ± 0.25 |
Compound A 55 mg/kg | 1.83 ± 0.76 | 2.83 ± 1.60 | 1.33 ± 1.04 | 1.83 ± 1.15 | 1.00 ± 0.86 | 0.83 ± 0.76 | 0.66 ± 0.57* |
Compound A 100 mg/kg | 1.83 ± 0.28 | 2.33 ± 1.52 | 1.50 ± 0.50 | 1.66 ± 0.57 | 1.50 ± 0.86 | 0.66 ± 1.15 | 1.33 ± 0.57** |
Dex 1.5 mg/kg | 2.25 ± 0.95 | 3.12 ± 2.09 | 1.37 ± 0.94 | 1.50 ± 1.08 | 1.25 ± 0.86 | 0.75 ± 0.64 | 1.00 ± 0.81** |
Compared to vehicle | *P < 0.05 | **P < 0.01 | ***P < 0.001 | Â | Â | Â | Â |