Figure 3

Ingenuity pathways analysis of 104 probes with false discovery rate-adjusted P values of less than 0.1. The analysis compares 20 twins affected with systemic autoimmune disease and 40 unrelated, matched controls. P values (blue bars) describing the confidence of the association of the data set with a given pathway are shown on the left vertical axis (-log(P value)). The cutoff threshold value (defined as P = 0.05) is also shown (horizontal yellow line). The ratio of the number of genes from the data set that map to a given pathway divided by the total number of molecules that comprise the pathway (orange line connecting blue bars) is shown on the right vertical axis. IL-6, interleukin-6; NF-κB, nuclear factor-kappa-B.