Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study

Table 1 Clinical manifestations of anti-topo I in African American versus Caucasian patients

Specificity	Topo I (n= 19)	Topo I + U1RNP (n= 6)	P
Age (yr, mean ± SD)	55.10 ± 12.9	46.6 ± 8.6
Male	26%	17%
Caucasian	68%	33%
African American	21%	67%	0.059
Latin	11%	0
Anti-Sm	0	33%	0.05
Proximal scleroderma	79%	50%
No sclerodermatous changes	5%	50%	0.03
Sclerodactyly only	16%	0
Pitting scars	74%	83%
ILD	74%	83%
Scleroderma kidney	16%	0
Overlap with SLE	0	50%	0.009
Elevated CPK	11%	50%	0.07
Overlap with PM/DM	0	33%	0.05

CPK, creatine phosphokinase; ILD, interstitial lung disease. P values are with the Fisher Exact test.

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