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Table 2 Clinical characteristic of six cases with anti-topo I coexisting with anti-snRNPs autoantibodies

From: Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study

Case

1

2

3

4

5

6

Anti-snRNPs

Sm, U1RNP

Sm, U1RNP

U1RNP

U1RNP

U1RNP

U1RNP

Race

Afr Am

Afr Am

Afr Am

Afr Am

Caucasian

Caucasian

Type of skin involvement

No scl

dcSSc

No scl

No scl

dcSSc

dcSSc

Pitting scars

Y

Y

Y

Y

 

Y

ILD

Y

Y

Y

Y

Y

 

Raynaud phenomenon

Y

Y

Y

Y

Y

Y

Pulmonary hypertension

 

Y

    

Esophageal dysmotility

     

Y

Flexion contracture

 

Y

   

Y

Acro-osteolysis

Y

    

P

SLE overlap/number of ACR criteria

Y

6

Y

5

N

2

Y

5

N

2

N

2

PM/DM overlap

Elevated CPK

 

DM

PM

  
  1. Afr Am, African American; dcSSc, diffuse cutaneous scleroderma; F, female; ILD, interstitial lung disease; M, male; Y, present; N, not present; No Scl, no sclerodermatous skin changes; P, possible.