Figure 4

Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA. This schematic representation, created by using Pathway Studio software, shows the connectivity between TGF-β and HEp-2 cell proteins identified as major targets of autoantibodies in SSc patients with unidentified ANA. Protein entities belonging to different functional groups are represented as different shapes. ANA: antinuclear antibody; CALR: calreticulin; CFL1: cofilin 1; FUS: fused in sarcoma; HDAC2: histone deacetylase 2; HNRNPA1: heterogeneous nuclear ribonucleoprotein A1; HNRNPA2B1: heterogeneous nuclear ribonucleoprotein A2/B1; HNRNPL: heterogeneous nuclear ribonucleoprotein L; HSPD1: heat shock 60-kDa protein 1; KHSRP: KH-type splicing regulatory protein (far upstream element-binding protein 2); LMNA: lamin A/C; PCBP2: poly(rC)-binding protein 2; PRDX2: peroxiredoxin 2; RB1: retinoblastoma-associated protein; RBBP4: retinoblastoma-binding protein 4; SOD2: superoxide dismutase 2, mitochondrial; SSc: systemic sclerosis; STMN1: stathmin 1; TGFB1: transforming growth factor β1; TPI1: triosephosphate isomerase 1; VIM: vimentin.