Skip to main content
Figure 1 | Arthritis Research & Therapy

Figure 1

From: Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis

Figure 1

ETA and/or BKB1 antagonist treatment improves static weight bearing tolerance. Static weight bearing tolerance was measured repeatedly at defined time points over the course of the study. Data are presented as mean ± SD per experimental group (n = 6), of weight on the right leg as a percentage of total weight on both hind limbs. Day 0, baseline pre-operative values. Repeated measures analysis of variance with Tukey post-hoc (Table 2) indicated that BKB1 antagonist treatment significantly ameliorated nociceptive tolerance in ACLT animals over the study period, as compared to saline-treated positive controls.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us