Skip to main content
Figure 4 | Arthritis Research & Therapy

Figure 4

From: Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis

Figure 4

Antagonist treatment protects joint histomorphometry. Sagittal sections. Left and middle columns, Safranin O/Fast Green FCF staining. Right column, type II collagen immunohistochemistry. Left column, low-power magnification: scale bar, 200 μm; original magnification 50 ×. Middle and right columns, high-power magnification: scale bar, 50 μ m; original magnification 200 ×. Conditions by rows: (a), (b), (c) no surgery and saline treatment; (d), (e), (f) sham surgery and saline treatment; (g), (h), (i) ACLT and saline treatment; (j), (k), (l) ACLT and BQ-123 treatment; (m), (n), (o) ACLT and R-954 treatment; (p), (q), (r) ACLT and BQ-123+R-954 dual treatment. Yellow arrows indicate loss of Safranin O staining, purple arrows indicate cartilage notching, and red arrow indicates an osteophyte. Black arrows indicate type II collagen immunostaining.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us