Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis

Table 2 Static weight bearing post-hoc tests

Contrast	Estimate	Standard error	z-score	P(>\|z\|)
None/Saline vs Sham/Saline	- 5.1697	1.9903	- 2.597	0.8746
Sham/Saline vs ACLT/Saline	6.5667	2.0155	3.258	0.019
ACLT/BQ-123 vs ACLT/Saline	2.5845	1.8841	1.372	0.1847
ACLT/R-954 vs ACLT/Saline	0.6951	1.9669	0.353	0.0002
ACLT/BQ-123+R-954 vs ACLT/Saline	0.2784	1.8503	0.15	0.0001

Tukey post-hoc tests were conducted following repeated measures ANOVA of the static weight bearing data. From left to right, the table columns present the contrast of interest, the parameter estimate from the linear matrix model, the standard error of that estimate, the standard z-score, and the associated P-value.

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