Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis

Table 5 OARSI histopathology scores

Group number	Surgery	Treatment	Mean OARSI score	SD
1	None	Saline	0.43	0.53
2	Sham	Saline	0.50	1.00
3	ACLT	Saline	17.00	5.77
4	ACLT	BQ-123	4.75	0.96^a
5	ACLT	R-954	4.25	2.02^b
6	ACLT	BQ-123+R-954	3.50	2.89^c

Four slides per condition were scored by two blinded examiners using the OARSI histopathology assessment system [46]. Results were averaged and are presented as mean scores per condition. Inter-examiner variation was within ± 5%. One-way ANOVA with Holm post-hoc: ^aP = 0.000017, ACLT/BQ-123 treatment versus ACLT/saline treatment; ^bP = 0.00001, ACLT/R-954 treatment versus ACLT/saline treatment; ^cP = 0.0000048, ACLT/BQ-123+R-954 dual treatment versus ACLT/saline treatment.

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