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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice

Figure 6

The effects of trichostatin A on the phenotype of bone marrow-derived dendritic cells. Bone marrow-derived dendritic cells were generated from SKG mice and incubated for 48 h with zymosan A and/or trichostatin A. Bone marrow-derived dendritic cells were stained for anti-MHC class II, anti-CD54, anti-CD86, anti-CD80, and anti-CD40. (A) The fluorescence activated cell sorting was shown by mean fluorescence intensity. Data are representative of three independent experiments. (B) The mean fluorescence intensity of each group was compared. Results are expressed as the mean ± SE of three independent experiments (P-values were N.S. in MHC class II, CD54 and CD80, P = 0.012 in CD86, P = 0.034 in CD40). N.S, not significant.

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