Figure 3

Locomotion in healthy and arthritic rats. (A) Knee joint angles (y-axis) during a complete walking cycle from one representative control animal (filled circles) and from one representative arthritic animal on day 3 after induction of arthritis which did not use the inflamed hindlimb at all (open circles). In the latter animal, the range of motion, defined as the difference between the maximum and minimum knee joint angles during one gait cycle, is reduced. (B) Range of motion in the inflamed and the contralateral noninflamed knee joint during the time course of antigen-induced arthritis (AIA) (circles) and in both knee joints of nonarthritic controls during the 21-day observation period (squares). BL : baseline. (C) Correlation of range of motion between inflamed and noninflamed knee joints. Each filled circle represents data from a single animal. ROM: range of motion.