Figure 5

Relationship between IRF5 haplotypes and expression in each of the expression data sets. The most common haplotypes of the interferon regulatory factor 5 (IRF5) gene were defined with eight tag SNPs and from H1 to H6 as described by Ferreiro-Neira et al. [4] (for haplotype definition, see Supplementary Table 5). H1 and H2 are systemic lupus erythematosus (SLE) protective haplotypes, and H6 is the risk haplotype. The remaining haplotypes are neutral. Univariate linear regression coefficients with their 95% confidence intervals (95% C.I.) for the relationship between each haplotype (coded 0, 1 or 2 if absent, heterozygous or homozygous, respectively) and IRF5 expression are shown. Coefficients significantly larger than 0 (with C.I. not crossing the dashed line at 0) indicate an association with increased IRF5 expression. Coefficients significantly smaller than 0 show association with decreased IRF5 expression. The values have been rescaled to allow the use of a single y-axis. Codes for each of the IRF5 expression data sets are given in Table 2.