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Table 2 Best multiple linear regression models with cis-polymorphisms accounting for IRF5 gene expression in each of the four data sets and in the average expression from CEU LCL (KSC)a

From: Cis-regulation of IRF5expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines

  Best linear regression model Polymorphism Pvalue in model
  Data set Adjusted r2 Model P Polymorphisms
K8 (Kwan et al. [29]) 0.31 1.7 × 10-5 rs3807306 4.0 × 10-6
    rs17424179 0.026
S (Stranger et al. [28]) 0.80 2.5 × 10-20 rs10954213 1.2 × 10-4
    rs3807306 2.4 × 10-3
    rs17424179 9.5 × 10-3
C (Cheung et al. [27]) 0.55 9.2 × 10-11 rs2280714 0.02
    rs10954213 0.02
KSC 0.69 1.3 × 10-13 rs10954213 5.1 × 10-3
    rs3807306 0.013
    rs17424179 0.011
D (Dixon et al. [30]) 0.28 1.3 × 10-13 CGGGG indel 2.4 × 10-6
    rs2280714 8.3 × 10-4
  1. aIRF5 = interferon regulatory factor 5 gene; LCL = lymphoblastoid cell line; CEU = European population from International HapMap Project database; KSC = average of standard normal transformed K8, S and C data. Statistical parameters of the best models are provided together with P values corresponding to independent contribution of each polymorphism to the model. Data sets in left column are representative IRF5 expression results.