Cis-regulation of IRF5expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines

Table 2 Best multiple linear regression models with cis-polymorphisms accounting for IRF5 gene expression in each of the four data sets and in the average expression from CEU LCL (KSC)^a

	Best linear regression model			Polymorphism Pvalue in model
	Data set	Adjusted r²	Model P	Polymorphisms
K8 (Kwan et al. [29])	0.31	1.7 × 10^-5	rs3807306	4.0 × 10^-6
			rs17424179	0.026
S (Stranger et al. [28])	0.80	2.5 × 10^-20	rs10954213	1.2 × 10^-4
			rs3807306	2.4 × 10^-3
			rs17424179	9.5 × 10^-3
C (Cheung et al. [27])	0.55	9.2 × 10^-11	rs2280714	0.02
			rs10954213	0.02
KSC	0.69	1.3 × 10^-13	rs10954213	5.1 × 10^-3
			rs3807306	0.013
			rs17424179	0.011
D (Dixon et al. [30])	0.28	1.3 × 10^-13	CGGGG indel	2.4 × 10^-6
			rs2280714	8.3 × 10^-4

^aIRF5 = interferon regulatory factor 5 gene; LCL = lymphoblastoid cell line; CEU = European population from International HapMap Project database; KSC = average of standard normal transformed K8, S and C data. Statistical parameters of the best models are provided together with P values corresponding to independent contribution of each polymorphism to the model. Data sets in left column are representative IRF5 expression results.

ISSN: 1478-6362