Table 1 Pathologic patterns in interstitial lung disease
From: The lung as a possible target for the immune reaction in myositis
Pattern | Pathologic findings | Associated outcome |
|---|---|---|
Acute interstitial pneumonia | Diffuse alveolar damage with hyaline membrane formation | >90% mortality at 30 days |
Cryptogenic organizing pneumonia or bronchiolitis obliterans with organizing Pneumonia | Intraluminal fibromyxoid tissue in the terminal and respiratory bronchioles | Good response to steroids |
Nonspecific interstitial pneumonia | Temporally and spatially homogeneous inflammatory injury with and without fibrosis | Good response except with fibrosing variant |
Usual interstitial pneumonia | Temporally heterogeneous, subpleural inflammatory injury with fibrosis and honeycombing | Less responsive to immunosuppressant therapies |