Figure 3
From: Disturbance of cytokine networks in Sjögren's syndrome
In secondary lymphoid organs and salivary glands of patients with primary Sjögren's syndrome, immature B cells settle down before further ontogenesis. Transitional type 1 B cells (BT1) evolve to BT2 cells, depending on the affinity of antigen for the B-cell antigen receptor (BCR) and the amount of B-cell activating factor (BAFF) of the TNF family. Should the BCR signal be low, they move to the marginal zone (MZB); should it be high, they generate germinal centers within the follicle (FO).