Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study

Table 3 Longitudinal associations between baseline clinical variables and 1-year MDHAQ pain, adjusted for age, gender, and baseline MDHAQ pain, among 157 RA patients in remission at baseline and 1 year

Variable	Mean MDHAQ Pain (95% CI)	P
Disease duration		0.02
≤3 years	1.6 (1.1, 2.2)
4-11 years	2.0 (1.6, 2.5)
≥12 years	2.4 (1.8, 3.0)
Rheumatoid factor/cyclic citrullinated peptide status		0.77
Seropositive	1.9 (1.5, 2.4)
Seronegative	2.1 (1.5, 2.6)
Tender-joint count		0.36
0	2.1 (1.6, 2.5)
1	1.7 (1.0, 2.5)
≥2	1.8 (0.9, 2.6)
Swollen-joint count		0.02
0	2.2 (1.8, 2.6)
1	1.3 (0.3, 2.3)
≥2	1.5 (1.0, 2.1)
C-reactive protein		0.77
<0.7 mg/L	1.9 (1.4, 2.5)
0.7-2.0 mg/L	2.0 (1.5, 2.5)
≥2.1 mg/L	2.0 (1.5, 2.5)
Patient global health assessment		0.03
<5	1.6 (0.9, 2.2)
5-14	1.7 (1.1, 2.2)
≥15	2.5 (2.0, 3.0)
Sharp score		0.53
≤1	2.1 (1.4, 2.7)
2-17	2.2 (1.6, 2.9)
≥18	1.8 (1.1, 2.5)
MDHAQ Function Scale		0.008
0	1.6 (1.0, 2.2)
0.1-0.9	1.5 (1.0, 2.0)
≥1.0	2.7 (2.1, 3.2)
Mental Health Index 5		0.43
≤70	2.2 (1.7, 2.4)
71-80	1.7 (1.1, 2.3)
>80	1.9 (1.4, 2.4)
MDHAQ Fatigue Scale		0.0001
<1.0	1.2 (0.7, 1.8)
1.0-3.9	1.8 (1.3, 2.3)
≥4.0	2.8 (2.3, 3.3)
MDHAQ Sleep Problems Score		0.001
0	1.6 (1.1, 2.0)
1	2.3 (1.8, 2.8)
≥2	3.1 (2.2, 4.0)
Arthritis Self-Efficacy Score		0.01
<78	2.2 (1.7, 2.7)
78-87	2.3 (1.8, 2.8)
≥88	1.4 (0.9, 1.9)
Modified Charlson Index		0.35
≤1	1.9 (1.5, 2.3)
>1	2.2 (1.6, 2.7)

MDHAQ, Multi-Dimensional Health Assessment Questionnaire; RA, rheumatoid arthritis. P values are from multivariable linear regression models.

ISSN: 1478-6362