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Table 1 Demographic and clinical characteristics of gout cases and controlsa

From: The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity

 

Gout

Controls

Characteristics

Māorib

EPb

WP

NZ Caucasian

FHS

ARIC

Māori

NZ EP

NZ WP

NZ Caucasian

FHS

ARIC

Number of cases/controls

229

261

187

327

67

153

343

348

142

638

47,12

6,969

Males, %

78

76

95

85

94

73

31

33

57

42

45

45

Mean ± 1 SD grandparents of stated ancestry

2.87 ± 1.15

3.10 ± 1.07

3.72 ± 0.59

4.00 ± 0.00

-

-

2.33 ± 1.20

2.46 ± 1.22

3.49 ± 0.86

4.00 ± 0.00

-

-

Mean serum urate at recruitment, mmol/L (range)

0.45

(0.21 to 0.98)

0.47

(0.19 to 0.98)

0.49

(0.17 to 0.72)

0.41

(0.18 to 1.07)

0.42

(0.21 to 0.58)

0.42

(0.11-0.70)

-

-

-

-

0.29

(0.07 to 0.63)

0.34

(0.03 to 0.72)

Confirmed tophi, %

38

39

56

30

-

-

-

-

-

-

-

-

Mean age at onset, years (range)

39

(15 to 74)

39

(15 to 74)

34

(15 to 75)

47

(15 to 83)

-

-

-

-

-

-

-

-

Mean age at recruitment, years (range)

-

-

-

-

38

(18 to 55)

54

(45-65)

44

(17 to 80)

44

(17 to 85)

38

(17 to 86)

52

(17 to 95)

37

(5 to 72)

54

(44 to 66)

Mean gout attacks in past year, n (range)

11

(0 to > 1/week)

11

(0 to > 1/week)

16

(0 to > 1/week)

7.5

(0 to > 1/week)

-

-

-

-

-

-

-

-

First-degree relative with gout, %

63

64

53

42

-

-

30

31

23

14

-

-

Allopurinol treatment, %

83

82

87

78

-

-

-

-

-

-

-

-

Probenecid treatment, %

6

6

13

6

-

-

-

-

-

-

-

-

Mean BMI (range)

35

(22 to 62)

35

(22 to 66)

38

(22 to 93)

30

(19 to 62)

29

(20 to 37)

28

(21-41)

32

(20 to 77)

32

(20 to 77)

35

(21 to 63)

28 (19 to 56)

27

(15 to 61)

27

(15 to 56)

Type 2 DM, %

28

30

18

13

15

7

10

9

11

7

4

7

Hypertension, %

63

63

46

49

-

-

16

16

17

14

-

-

Dyslipidemia, %

51

52

53

48

-

-

12

12

11

16

-

-

Cardiovascular disease, %

40

38

20

37

-

-

3

3

1

6

-

-

Renal disease, %

30

30

22

22

21

-

2

2

1

2

6

-

  1. aARIC = Atherosclerosis Risk in Communities study; BMI = body mass index; DM = diabetes mellitus; EP = Eastern Polynesian; FHS = Framingham Heart Study; NZ = New Zealand; SD = standard deviation; WP = Western Polynesian. bFull clinical data were available in 76% of Māori and 63% of EP gout cases (> 90% in other sample sets).
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Arthritis Research & Therapy

ISSN: 1478-6362

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