Skip to main content

Table 1 Demographic and clinical characteristics of gout cases and controlsa

From: The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity

  Gout Controls
Characteristics Māorib EPb WP NZ Caucasian FHS ARIC Māori NZ EP NZ WP NZ Caucasian FHS ARIC
Number of cases/controls 229 261 187 327 67 153 343 348 142 638 47,12 6,969
Males, % 78 76 95 85 94 73 31 33 57 42 45 45
Mean ± 1 SD grandparents of stated ancestry 2.87 ± 1.15 3.10 ± 1.07 3.72 ± 0.59 4.00 ± 0.00 - - 2.33 ± 1.20 2.46 ± 1.22 3.49 ± 0.86 4.00 ± 0.00 - -
Mean serum urate at recruitment, mmol/L (range) 0.45
(0.21 to 0.98)
0.47
(0.19 to 0.98)
0.49
(0.17 to 0.72)
0.41
(0.18 to 1.07)
0.42
(0.21 to 0.58)
0.42
(0.11-0.70)
- - - - 0.29
(0.07 to 0.63)
0.34
(0.03 to 0.72)
Confirmed tophi, % 38 39 56 30 - - - - - - - -
Mean age at onset, years (range) 39
(15 to 74)
39
(15 to 74)
34
(15 to 75)
47
(15 to 83)
- - - - - - - -
Mean age at recruitment, years (range) - - - - 38
(18 to 55)
54
(45-65)
44
(17 to 80)
44
(17 to 85)
38
(17 to 86)
52
(17 to 95)
37
(5 to 72)
54
(44 to 66)
Mean gout attacks in past year, n (range) 11
(0 to > 1/week)
11
(0 to > 1/week)
16
(0 to > 1/week)
7.5
(0 to > 1/week)
- - - - - - - -
First-degree relative with gout, % 63 64 53 42 - - 30 31 23 14 - -
Allopurinol treatment, % 83 82 87 78 - - - - - - - -
Probenecid treatment, % 6 6 13 6 - - - - - - - -
Mean BMI (range) 35
(22 to 62)
35
(22 to 66)
38
(22 to 93)
30
(19 to 62)
29
(20 to 37)
28
(21-41)
32
(20 to 77)
32
(20 to 77)
35
(21 to 63)
28 (19 to 56) 27
(15 to 61)
27
(15 to 56)
Type 2 DM, % 28 30 18 13 15 7 10 9 11 7 4 7
Hypertension, % 63 63 46 49 - - 16 16 17 14 - -
Dyslipidemia, % 51 52 53 48 - - 12 12 11 16 - -
Cardiovascular disease, % 40 38 20 37 - - 3 3 1 6 - -
Renal disease, % 30 30 22 22 21 - 2 2 1 2 6 -
  1. aARIC = Atherosclerosis Risk in Communities study; BMI = body mass index; DM = diabetes mellitus; EP = Eastern Polynesian; FHS = Framingham Heart Study; NZ = New Zealand; SD = standard deviation; WP = Western Polynesian. bFull clinical data were available in 76% of Māori and 63% of EP gout cases (> 90% in other sample sets).