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Table 1 Main clinical, serological, histological, genetic characteristics of focal sialoadenitis

From: Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection

Variable Primary Sjögren's syndrome Hepatitis C virus HIV-related DILS
Sicca symptoms Present Present Present
Parotid swelling Moderate to severe Mild to moderate Moderate to severe
Extra-glandular manifestations Mainly pulmonary, gastrointestinal, renal, and neurologic involvement Mainly gastrointestinal and musculo-skeletal involvement Mainly musculoskeletal, pulmonary, gastrointestinal, and neurologic involvement
Infiltrating lymphocytic phenotype CD4+ T cells CD4+ T cells CD8+ T cells
Autoantibodies High-frequency RF, ANA, anti-Ro/SSA and anti-La/SSB High frequency of RF Very low frequency of ANA, anti-Ro/SSA and anti-La/SSB Low-frequency RF, ANA
HLA association B8, DR2 and DR3 DR-11(DR5) B45, B49, B50, DR11(DR5), and DRw6
  1. Main characteristics of focal sialoadenitis in primary Sjögren's syndrome, hepatitis C virus-infected patients and HIV-infected patients developing diffuse infiltrative lymphocytosis syndrome (DILS). ANA: antinuclear antibodies; RF, rheumatoid factor. Modified from Basu and colleagues [59].