Network pathway analysis of up-regulated genes in the gene category immune response. (a to d) Four different networks constructed by the 56 up-regulated genes. Genes and gene products are represented as individual nodes whose shapes represent the functional class of the gene products. The biologic relation between two nodes is represented as an edge (line). All edges are supported by at least one reference from the Ingenuity Pathways Knowledge Base (IPKB). Genes in colored nodes are overexpressed. Genes in uncolored nodes are not, but are depicted by the computationally generated networks on the basis of evidence stored in the IPKB indicating a strong biologic relevance to that network.