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Table 2 Top 15 deviated gene categories of overexpressed genes in rheumatoid arthritis bone marrow compared with osteoarthritis bone marrow

From: Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis

Gene category List hits Population hits EASE score
(GO biological process) (Total = 348) (Total = 10,937)  
response to external stimulus 67 1263 2.52E-05
   response to biotic stimulus 61 821 6.47E-10
   defense response 57 756 1.62E-09
   immune response 56 682 9.89E-11
   response to pest/pathogen/parasite 27 444 1.92E-03
   antigen processing, endogenous antigen via MHC class I 4 12 5.63E-03
response to stress 37 784 1.57E-02
signal transduction 97 2196 3.43E-04
   intracellular signaling cascade 47 761 1.62E-05
   protein kinase cascade 12 155 1.04E-02
   activation of MAPK 4 16 1.30E-02
phosphate metabolism 33 662 1.13E-02
   phosphorylation 28 524 8.90E-03
   protein amino acid phosphorylation 26 478 9.74E-03
RNA splicing, via transesterification reactions 8 83 1.61E-02
  1. EASE, Expression Analysis Systematic Explorer software, Version 2.0; Gene Ontology database; GO, gene ontology; MAPK, mitogen activated protein kinase; MHC, major histocompatibility complex.
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Arthritis Research & Therapy

ISSN: 1478-6362

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