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Table 2 Top 15 deviated gene categories of overexpressed genes in rheumatoid arthritis bone marrow compared with osteoarthritis bone marrow

From: Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis

Gene category

List hits

Population hits

EASE score

(GO biological process)

(Total = 348)

(Total = 10,937)

 

response to external stimulus

67

1263

2.52E-05

   response to biotic stimulus

61

821

6.47E-10

   defense response

57

756

1.62E-09

   immune response

56

682

9.89E-11

   response to pest/pathogen/parasite

27

444

1.92E-03

   antigen processing, endogenous antigen via MHC class I

4

12

5.63E-03

response to stress

37

784

1.57E-02

signal transduction

97

2196

3.43E-04

   intracellular signaling cascade

47

761

1.62E-05

   protein kinase cascade

12

155

1.04E-02

   activation of MAPK

4

16

1.30E-02

phosphate metabolism

33

662

1.13E-02

   phosphorylation

28

524

8.90E-03

   protein amino acid phosphorylation

26

478

9.74E-03

RNA splicing, via transesterification reactions

8

83

1.61E-02

  1. EASE, Expression Analysis Systematic Explorer software, Version 2.0; Gene Ontology database; GO, gene ontology; MAPK, mitogen activated protein kinase; MHC, major histocompatibility complex.