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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model

Figure 1

Experimental design of the sequence of events for the entire course of the experiment. After evaluations that included measurements of paw edematous swelling and pain threshold, the animals were sacrificed for histology and immunohistochemistry. 1D, one dose; 3D, three doses; 3D6d, follow-up at the 6th day after three doses; CFA, complete Freund's adjuvant; HA, hyaluronan; No-tr, no treatment; SA, saline.

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