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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model

Figure 2

Results of edema (a) and pain behavioral (b) assessments. Data were calculated before treatment at the conditions of pre-complete Freund's adjuvant (CFA)-induced and post-CFA-induced arthritis and after treatment at conditions of one dose (1D), three doses (3D), and follow-up at the 6th day after three doses (3D6d) in hyaluronan (HA), saline (SA), and 'no treatment' (No-tr) groups. Each bar represents the mean ± standard deviation in body weight and mean ± standard error of the mean in paw circumference and withdrawal threshold. #P <0.05, Student t test for comparison of pre- and post-arthritic conditions before treatment. *P <0.05, Bonferroni post hoc test for comparison of difference between groups at dosages of 1D, 3D, and 3D6d after treatment.

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