Results of edema (a) and pain behavioral (b) assessments. Data were calculated before treatment at the conditions of pre-complete Freund's adjuvant (CFA)-induced and post-CFA-induced arthritis and after treatment at conditions of one dose (1D), three doses (3D), and follow-up at the 6th day after three doses (3D6d) in hyaluronan (HA), saline (SA), and 'no treatment' (No-tr) groups. Each bar represents the mean ± standard deviation in body weight and mean ± standard error of the mean in paw circumference and withdrawal threshold. #P <0.05, Student t test for comparison of pre- and post-arthritic conditions before treatment. *P <0.05, Bonferroni post hoc test for comparison of difference between groups at dosages of 1D, 3D, and 3D6d after treatment.