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Table 1 Results of histopathological scores of synovium for sections in arthritic ankle joint sampled from three treatment groups

From: Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model

Dose

Group

Intimal

hyperplasia

Subintimal

fibrosis

Lymphocytic infiltration

Vascularity

Aggregate

score

1D

HA

2.45 ± 0.11

2.60 ± 0.11

1.50 ± 0.11a, b

2.05 ± 0.11

7.80 ± 0.26a, b

 

SA

2.60 ± 0.11

2.60 ± 0.11

2.50 ± 0.11

2.10 ± 0.12

9.10 ± 0.31

 

No-tr

2.65 ± 0.11

2.65 ± 0.10

2.95 ± 0.05

2.20 ± 0.12

9.75 ± 0.24

 

cP value among groups

P > 0.05

P > 0.05

P <0.001

P > 0.05

P <0.001

3D

HA

2.50 ± 0.11

2.70 ± 0.11

1.40 ± 0.13a, b

2.20 ± 0.09

8.05 ± 0.31a, b

 

SA

2.80 ± 0.09

2.70 ± 0.10

2.55 ± 0.11

2.15 ± 0.11

9.55 ± 0.28

 

No-tr

2.80 ± 0.09

2.70 ± 0.11

2.85 ± 0.08

2.20 ± 0.14

9.95 ± 0.32

 

cP value among groups

P > 0.05

P > 0.05

P <0.001

P > 0.05

P <0.001

3D6d

HA

2.50 ± 0.11

2.50 ± 0.11

1.40 ± 0.11a, b

2.15 ± 0.11

7.85 ± 0.25a, b

 

SA

2.70 ± 0.11

2.60 ± 0.10

2.77 ± 0.10

2.20 ± 0.14

9.6 ± 0.36

 

No-tr

2.70 ± 0.11

2.70 ± 0.11

2.85 ± 0.08

2.40 ± 0.11

10.05 ± 0.33

  1. Sections were stained with hematoxylin and eosin. Values are presented as mean ± standard error of the mean. aP < 0.05, showed statistically significant differences between hyaluronan (HA) and saline (SA) groups; bP < 0.05, showed statistically significant differences between HA and 'no treatment' (No-tr) groups; Mann-Whitney U ranked tests were used for between-group comparisons. cTested with Kruskal-Wallis test. 1D, one dose; 3D, three doses; 3D6d, follow-up at the 6th day after three doses.