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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Analysis of IL-17+cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

Figure 3

Peripheral and synovial CD4+IL-17+ T cell levels in spondyloarthritis, rheumatoid arthritis and controls. Analysis of (a) peripheral blood (PB) and (b) synovial fluid (SF) CD4+IL-17+ T cells in spondyloarthritis (SpA) patients (PB n = 30, SF n = 11), rheumatoid arthritis (RA) patients (PB n = 14, SF n = 7), osteoarthritis (OA) patients (PB n = 10) and healthy controls (C) (PB n = 12). Similar levels of PB and SF CD4+IL-17+ T cells after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin or Staphylococcus aureus Enterotoxin B (SEB) antibodies are seen when SpA patients are compared to RA patients. The frequency of PB CD4+IL-17+ T cells was only significantly lower in SpA patients than in controls when stimulated with SEB antibodies (P < 0.05).

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Arthritis Research & Therapy

ISSN: 1478-6362

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