Skip to main content
Figure 2 | Arthritis Research & Therapy

Figure 2

From: Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

Figure 2

Transcriptional regulatory network for osteoclastogenesis. RANK (Receptor activator of NF-κB) signaling together with calcium signaling drives expression of NFATc1 (Nuclear factor of activated T cells, cytoplasmic 1) and its targets, resulting in osteoclastogenesis. This process also requires releasing the 'brakes' on NFATc1 expression and osteoclastogenesis that are imposed by transcriptional repressors, including inhibitors of differentiation/DNA binding (Ids), MafB (v-maf musculoaponeurotic fibrosarcoma oncogene family protein B), interferon regulatory factor (IRF)-8 and B cell lymphoma 6 (Bcl6). There is crosstalk between the activating and suppressive pathways, as Blimp1 (B lymphocyte-induced maturation protein-1) that is induced by NFATc1 suppresses expression of MafB, IRF-8 and Bcl6. ITAM, immunoreceptor tyrosine-based activation motif; MAPK, mitogen-activated protein kinase.

Back to article page