Table 1 Chips and markers used on the IMPACT platform*
From: Novel multiplex technology for diagnostic characterization of rheumatoid arthritis
| Chip name | Chip components | |
|---|---|---|
| Antigens | Capture antibodies | |
| Synovial antigen chip 1 | Histone 2B/e (1-20) | |
| Biglycan (247-266) | ||
| Fibromodulin (246-265) | ||
| Vimentin (58-77) (Cit 64, 69, 71) | ||
| Acetyl-calpastatin (184-210) | ||
| Fibromodulin (201-220) | ||
| Profilaggrin (293-310) (Cit 301, 302) | ||
| Clusterin (170-188) | ||
| Fibrinogen A (31-50) (Cit 35, 38, 42) | ||
| Fibrinogen A (616-635) (Cit 621, 627, 630) | ||
| Synovial antigen chip 2 | Histone 2A (95-114) | |
| Profilaggrin (293-310) (Cit 301, 305) | ||
| HSP60 (287-297) | ||
| Serine protease 11 (433-452) | ||
| Osteoglycin (177-196) | ||
| Apolipoprotein E (277-296) (Cit 278, 292) | ||
| Clusterin (334-353) (Cit 336, 339) | ||
| COMP (453-472) | ||
| CID 1 | anti-CRP | |
| anti-IgA (for RF measurement) | ||
| anti-IgM (for RF measurement) | ||
| CID 3 chip 1 | Cit peptide 1 | |
| Cit peptide 2 | ||
| Cit peptide 3 | ||
| Cit peptide 4 | ||
| CID 3 chip 2 | Cit peptide 5 | |
| Cit peptide 6 | ||
| Cit peptide 7 | ||
| Cit peptide 8 | ||
| Cit peptide 9 | ||
| Cit peptide 10 | ||
| Cit peptide 11 | ||
| CID 4 | anti-MMP 3 | |
| anti-IL-6 | ||
| anti-S100 protein A8/A9 | ||
| anti-E-Selectin | ||
| anti-HABP | ||
| Bone | anti-PTH | |
| anti-βCrosslaps | ||
| anti-Osteocalcin | ||
| anti-P1NP | ||