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Table 2 Performance characteristics of multiplex-assayed autoantibody profiles in the diagnosis of rheumatoid arthritis

From: Novel multiplex technology for diagnostic characterization of rheumatoid arthritis

Number of positive biomarkers* PPV NPV Sensitivity Specificity
1+ markers 79.5% 92.6% 96.7% 62.5%
2+ markers 91.8% 89.7% 93.3% 87.5%
3+ markers 95.3% 79.8% 84.2% 93.8%
4+ markers 95.9% 61.1% 59.2% 96.3%
  1. *Biomarker panel: histone 2B/e (1-20), vimentin (58-77) (Cit 64, 69, 71), fibrinogenA (616-635) (Cit 621, 627, 630), COMP (453-472), profilaggrin (293-310) (Cit 301, 305), RF-IgA. The cut-off value for positivity was defined as three times the mean value obtained in samples from healthy individuals. PPV, positive predictive value; NPV, negative predictive value.