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Table 1 Baseline characteristics of the patientsa

From: Antibodies toward infliximab are associated with low infliximab concentration at treatment initiation and poor infliximab maintenance in rheumatic diseases

 

RA (n= 17)

SpA (n= 91)

Characteristics

ATIpos (n= 7)

ATIneg (n= 10)

Pvalue

ATIpos (n= 14)

ATIneg (n= 77)

Pvalue

Age, years

49 (28 to 65)

47 (36 to 64)

0.7

47 (36 to 73)

44 (14 to 76)

0.2

Body mass index, kg/m2

25.9 (20.2 to 34.8)

23.5 (16.4 to 34.6)

0.5

24.8 (17.5 to 32.8)

26.1 (15.8 to 45.8)

0.1

Disease duration, years

6.0 (1 to 12)

10 (2 to 30)

0.07

8.9 (0 to 24)

5 (0 to 24)

0.3

Infliximab dose, mg/kg

3.0 (2.8 to 3.7)

3.6 (2.6 to 5.4)

0.09

4.9 (2.9 to 5.7)

5.0 (2.8 to 6.7)

0.4

Concomitant treatments

   MTX, n (%)

3 (43)

6 (60)

0.8

0 (0)

25 (32)

0.03

   Prednisone, n (%)

4 (57)

8 (80)

0.6

2 (14)

12 (16)

0.8

ESR, mm/hour

14 (7 to 58)

24 (2 to 114)

0.5

8 (2 to 54)

10 (1 to 89)

0.6

CRP, mg/L

10 (3 to 81)

16 (3 to 124)

0.9

3 (1 to 72)

5 (1 to 74)

0.9

  1. aATI: antibodies toward infliximab; ATIpos: ATI detected at least once during follow-up; ATIneg: ATI not detected; RA: rheumatoid arthritis; SpA: spondyloarthritis; MTX: methotrexate; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein. Results are given as medians (ranges) unless otherwise indicated.