Figure 6
Pathway generated by ingenuity pathway analysis with proteins identified as specific target antigens. Solid lines indicate direct interactions. Dashed lines indicate indirect interactions. Arrows indicate stimulation. Mass spectrometry-identified proteins are depicted in grey. ACTB: actin, β; ACTG1: actin, γ1; ANXA2: annexin A2; ANXA5: annexin A5; CCT2: chaperonin containing TCP1, subunit 2 (β); DLD: dihydrolipoamide dehydrogenase; ENO1: enolase 1, α; EZR: ezrin; FABP5: fatty acid-binding protein 5; FH: fumarate hydratase; GRB2: growth factor receptor-bound protein 2; HNRNPD: heterogeneous nuclear ribonucleoprotein D; HSP90AA2: heat shock protein 90 α (cytosolic), class A member 2; HSPB1: HSPB1: heat shock 27-kDa protein 1; IL4: interleukin 4; IMPDH2: IMP (inosine 5'-monophosphate) dehydrogenase; IRS1: insulin receptor substrate 1; KHSRP: KH-type splicing regulatory protein = FUBP2; LMNA: lamin A/C; MSN: moesin; NPM1: nucleophosmin (nuclear phosphoprotein B23, numatrin); PDIA3: protein disulphide isomerase, family A, member 3; PPIA: peptidylpropyl isomerase A; PRDX3: peroxiredoxin 3; RDX: radixin; RPLPO: ribosomal protein, large, P0; SEMA4D: Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytosolic domain (semaphorin) 4D; TNF: tumour necrosis factor; TOMM40: translocase of outer mitochondrial membrane 40 homolog (yeast); TUFM: Tu translation elongation factor, mitochondrial; UGDH: UDP-glucose 6-dehydrogenase; VCL: vinculin; VDAC2: voltage-dependent anion channel 2.