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Table 1 Mass spectrometry data of vascular smooth muscle cell protein spots identified as specific target antigena

From: Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic approach

Spot ID

Protein

SwissProt accession number

Theoretical/estimated MW, kDa

Theoretical/estimated pI

Number of unique identified peptidesc, d

Total ion scored

Best ion scored

Sequence coverage, %d

173

Vinculin

[Swiss Prot:VINC_HUMAN]

124/122

5.5/6.4

3/14

39

19

19

294

Putative heat shock protein HSP90, subunit α2b

[Swiss Prot:HS902_HUMAN]

39/94

4.6/5.6

1/5

40

40

22

340

Far upstream element-binding protein 2

[Swiss Prot:FUBP2_HUMAN]

73/88

6.8/7.2

4-2/10-9

67-46

24-32

21-16

341

Far upstream element-binding protein 2

[Swiss Prot:FUBP2_HUMAN]

73/88

6.8/7.4

5-5/12-11

84-119

24-35

25-19

344

Far upstream element-binding protein 2

[Swiss Prot:FUBP2_HUMAN]

73/88

6.8/7.8

4/11

85

37

22

580

Lamin A/Cb

[Swiss Prot:LMNA_HUMAN]

74/67

6.6/6.5

1/10

24

24

16

 

Coatomer subunit αb

[Swiss Prot:COPA_HUMAN]

138/67

7.7/6.5

1/3

37

37

3

598

UDP-glucose 6-dehydrogenaseb

[Swiss Prot:UGDH_HUMAN]

55/66

6.6/6.7

2/4

46

39

11

609

No identified protein

 

/66

/5.9

    

683

No identified protein

 

/60

/5.8

    

686

Protein disulphide-isomerase A3

[Swiss Prot:PDIA3_HUMAN]

57/59

6.0/6.1

11-11/16-17

1,048-804

140-106

42-44

694

Protein disulphide-isomerase A3

[Swiss Prot:PDIA3_HUMAN]

57/59

6.0/6.3

8-8/14-13

460-362

86-63

38-35

702

No identified protein

 

/59

/7.6

    

734

T-complex protein 1, subunit β

[Swiss Prot:TCPB_HUMAN]

57/57

6.0/6.5

8-12/14-14

503-519

121-121

39-40

852

No identified protein

 

/51

/5.2

    

877

No identified protein

 

/49

/7.0

    

918

ANKRD26-like family C member 1A

[Swiss Prot:A26CA_HUMAN]

121/47

5.8/5.7

3-4/6-6

242-251

97-107

9-7

 

Actin cytoplasmic 1

[Swiss Prot:ACTB_HUMAN]

42/47

5.3/5.7

5/10

390

131

53

 

Actin cytoplasmic 2

[Swiss Prot:ACTG_HUMAN]

42/47

5.3/5.7

7/9

418

107

38

953

26S protease regulatory subunit 8

[Swiss Prot:PRS8_HUMAN]

46/46

7.1/7.6

9-2/15-7

180-53

41-31

45-21

 

Mitochondrial import receptor subunit TOMM40 homolog

[Swiss Prot:TOM40_HUMAN]

38/46

6.8/7.6

1-1/2-4

48-66

48-38

7-15

 

Fumarate hydratase mitochondrial precursorb

[Swiss Prot:FUMH_HUMAN]

55/46

8.9/7.6

1/3

61

61

7

1108

Nucleophosmin

[Swiss Prot:NPM_HUMAN]

33/39

4.6/5.1

3-4/5-5

83-203

39-65

24-25

1216

Annexin A2

[Swiss Prot:ANXA2_HUMAN]

39/35

7.6/8.0

11-13/8-10

650-265

99-51

45-38

  1. aMW: molecular weight, pI: isoelectric point, ANKRD26: ankyrin repeat domain-containing protein 26, TOMM40: translocase of outer mitochondrial membrane 40 homolog (yeast). bOnly one peptide of the protein was recognised by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass spectrometry; identification spectrum for each protein spot is given in Additional file 5;cindicate number of unique identified peptides in MSMS and in MS+MSMS searches; didentification was performed twice. When available, both values are given.
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Arthritis Research & Therapy

ISSN: 1478-6362

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