Table 2 Sequential analysis of variance table for the regression model for patients ≤ 65 years of age.

   Age

1

41.844

180.7462

< 2e-16

   Status

1

23.888

103.1865

< 2e-16

   Genotype

14

51.14

15.7787

< 2e-16

   Sex

1

0.516

2.2304

0.1357

Interactions effects

   Genotype * Status

13

4.202

1.3961

0.1551

   (Status + Genotype) * Age

13

1.671

0.5552

0.8896

   (Status + Genotype) * RCS(Age)

55

14.932

1.1727

0.1892

Error

   Residual

744

172.24