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Table 3 HI3L1 genotypes and the effect on serum YKL-40 levels in patients with rheumatoid arthritis and controls.

From: Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects

SNP

CHI3L1position

Controls (n = 605)

F df = 603

P-value

RA age ≤ 65 years (n = 238)

F

Df = 236

P-value

rs6691378

g.-1371G/A

Serum YKL-40 ng/ml

  

serum YKL-40 ng/ml

  
 

G/G

46 (44 to 48)

6.63

0.0014

67 (61 to 74)

2.85

0.06

 

G/A

54 (50 to 59)

  

77 (62 to 95)

  
 

A/A

47 (34 to 68)

  

151 (71 to 323)

  

rs10399931

g.-329C/T

      
 

C/C

56 (53 to 58)

83.13

< 2.2e-16

80 (71 to 89)

12.34

8.0e-06

 

C/T

40 (38 to 42)

  

61 (53 to 70)

  
 

T/T

25 (22 to 29)

  

35 (24 to 49)

  

rs10399805

g.-247G/A

      
 

G/G

45 (44 to 47)

7.47

6.3e-3

67 (61 to 74)

2.69

0.07

 

G/A

54 (50 to 59)

  

76 (61 to 94)

  
 

A/A

48 (34 to 68)

  

151 (71 to 323)

  

rs4950928

g.-131C/G

      
 

C/C

56 (53 to 58)

102.32

< 2.2e-16

81 (73 to 90)

18.91

2.4e-08

 

C/G

38 (38 to 40)

  

59 (51 to 68)

  
 

G/G

25 (22 to 28)

  

31 (22 to 43)

  

rs7515776

g.+48A/T

      
 

A/A

46 (44 to 48)

7.02

9.7e-3

67 (61 to 74)

1.76

0.17

 

A/T

54 (50 to 59)

  

77 (62 to 95)

  
 

T/T

48 (33 to 70)

  

119 (62 to 231)

  

rs1538372

g.+1219G/A

      
 

G/G

56 (53 to 59)

46.93

< 2.2e-16

78 (68 to 89)

7.58

6.5e-3

 

G/A

43 (41 to 45)

  

69 (60 to 78)

  
 

A/A

34 (30 to 37)

  

45 (34 to 57)

  

rs2071579

g.+2117G/C

      
 

C/C

56 (52 to 59)

21.91

6.5e-10

72 (62 to 84)

6.31

0.0022

 

C/G

47 (44 to 49)

  

76 (67 to 86)

  
 

G/G

39 (36 to 42)

  

52 (43 to 62)

  

rs880633

g.+2950C/T

      
 

C/C

56 (52 to 59)

21.91

6.7e-10

72 (62 to 84)

6.31

0.0022

 

C/T

47 (44 to 49)

  

76 (67 to 86)

  
 

T/T

39 (36 to 42)

  

52 (43 to 62)

  
  1. Serum concentrations of YKL-40 are given as median ± 95% CI.
  2. CHI3L1, chitinase 3-like 1 gene; CI, confidence interval; RA, rheumatoid arthritis; SNP, single nucleotide polymorphism.