Table 5 Association of CHI3L1 SNPs with rheumatoid arthritis

rs6691378

Promoter

g.-1371G/A

n (%)

n (%)

G/G

249 (80.8)

468 (77.4)

0.48

G/A

56 (18.2)

130 (21.5)

A/A

3 (1.0)

7 (1.2)

Allele

G

554 (89.9)

1,066 (88.1)

0.24

A

62 (10.1)

144 (11.9)

rs10399931

Promoter

g.-329C/T

C/C

175 (56.8)

360 (59.5)

0.61

C/T

116 (37.7)

208 (34.4)

T/T

17 (5.5)

37 (6.1)

Allele

C

466 (75.6)

928 (76.7)

0.62

T

150 (24.4)

282 (23.3)

rs10399805

Promoter

g.-247G/A

G/G

248 (80.5)

464 (76.7)

0.38

G/A

56 (18.2)

134 (22.1)

A/A

4 (1.3)

7 (1.2)

Allele

G

552 (89.6)

1,062 (87.8)

0.25

A

64 (10.4)

148 (12.2)

rs4950928

Promoter

g.-131C/G

C/C

190 (61.7)

390 (64.5)

0.61

C/G

101 (32.8)

179 (29.5)

G/G

17 (5.5)

36 (6.0)

Allele

C

481 (78.1)

959 (79.3)

0.56

G

135 (21.9)

251 (20.7)

rs7515776

Intron 1/ exon 1

g.+48A/T

A/A

247 (80.2)

467 (77.2)

0.20

A/T

55 (17.9)

132 (21.8)

T/T

6 (1.9)

6 (1.0)

Allele

A

549 (89.1)

1,066 (88.1)

0.52

T

67 (10.9)

144 (11.9)

rs1538372

Intron 2/ exon 3

g.+1219G/A

G/G

137 (44.5)

277 (45.8)

0.93

G/A

137 (44.5)

262 (43.3)

A/A

34 (11.0)

66 (10.9)

Allele

G

411 (66.7)

816 (67.4)

0.76

A

205 (33.3)

394 (32.6)

rs2071579

intron 4/ exon 4

g.+2117G/C

C/C

63 (20.5)

123 (20.3)

0.89

C/G

149 (48.4)

302 (49.9)

G/G

96 (31.2)

180 (29.8)

Allele

C

275 (44.6)

548 (45.3)

0.79

G

341 (55.4)

662 (54.7)

rs880633

exon 5

g.+2950C/T

C/C

96 (31.2)

180 (29.8)

0.88

C/T

149 (48.4)

303 (50.0)

T/T

63 (20.4)

122 (20.2)

Allele

C

341 (55.4)

663 (54.8)

0.82

T

275 (44.6)

547 (45.2)