Table 4 Bone-erosive damage assessed on the basis of US scores across TGF-β 869C/T SNPs according to ACPA and RF statusa
Patient status | CC | CT | TT | P value |
|---|---|---|---|---|
ACPA-positive | ||||
Mean overall patient TES (± SD) | 39.5 ± 21.4 | 39.4 ± 26.3 | 23.7 ± 13.7 | NS |
Mean MCP TES (± SD) | 16.7 ± 8.7 | 14.2 ± 9.1 | 11.2 ± 5.1 | NS |
Mean PIP TES (± SD) | 9.4 ± 11.9 | 11.9 ± 9.8 | 7.7 ± 6.7 | NS |
Mean MTP TES (± SD) | 13.3 ± 8.8 | 13.1 ± 8.3 | 4.75 ± 4.2 | P = 0.008, Pc < 0.01; CC vs. TT |
P = 0.01, Pc < 0.05; CT vs. TT | ||||
ACPA-negative | ||||
Mean overall patient TES (± SD) | 24 ± 21.9 | 22 ± 11.1 | 38 ± 17.1 | NS |
Mean MCP TES (± SD) | 11.5 ± 8.4 | 7.1 ± 3.6 | 14 ± 4.7 | P < 0.05, Pc = NS; CT vs. TT |
Mean PIP TES (± SD) | 5.6 ± 5.3 | 6.1 ± 5.2 | 14.2 ± 7.8 | P < 0.05, Pc = NS; CC vs. TT |
Mean MTP TES (± SD) | 6.8 ± 9.4 | 8.6 ± 4.8 | 9.8 ± 8.3 | NS |
RF-positive | ||||
Mean overall patient TES (± SD) | 38 ± 22.4 | 37.6 ± 25.7 | 23.7 ± 13.7 | NS |
Mean MCP TES (± SD) | 16.4 ± 8.9 | 13.8 ± 8.9 | 11.2 ± 5 | NS |
Mean PIP TES (± SD) | 8.6 ± 7.6 | 11 ± 9.6 | 7.7 ± 6.7 | NS |
Mean MTP TES (± SD) | 13 ± 9.1 | 12.7 ± 8.1 | 4.7 ± 4.2 | P = 0.01, Pc < 0.05; CC vs. CT |
P = 0.01, Pc < 0.05; CT vs. TT | ||||
RF-negative | ||||
Mean overall patient TES (± SD) | 16.5 ± 8.7 | 27.4 ± 16.5 | 38 ± 17.1 | P = 0.03, Pc = NS; CC vs. TT |
Mean MCP TES (± SD) | 7.5 ± 3.3 | 8.8 ± 6 | 14 ± 4.7 | P = 0.03, Pc = NS; CC vs. TT |
Mean PIP TES (± SD) | 5 ± 3.5 | 9 ± 6.8 | 14.2 ± 7.8 | P = 0.03, Pc < 0.05; CC vs. TT |
Mean MTP TES (± SD) | 4 ± 3.5 | 9.6 ± 8.3 | 9.8 ± 8.3 | NS |