Figure 6

Act1 shRNA completely inhibited IL-17-induced RAGE production in RA-FLS. (a) RA-FLS were treated with Act-1 shRNA. Act-1 mRNA was analyzed by real-time PCR. (b) RA-FLS were pretreated with Act-1 shRNA for 24 h, and then 10 ng/ml IL-17 was added for 24 h. RAGE mRNA was analyzed by real-time PCR. *P < 0.05 compared to untreated cells and #P < 0.05 compared to IL-17 treated cells.