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Table 2 Comparison of anti-CL and anti-β2 GPI antibodies detected in ELISA and MLDA

From: Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay

anti-CL IgG MLDA    anti-CL IgM MLDA   
   positive negative n    positive negative n
ELISA positive 32 15 47 ELISA positive 22 11 33
  negative 11 171 182   negative 20 176 196
  n 43 186 229   n 42 187 229
anti-β2 GPI IgG MLDA    anti-β2 GPI IgM MLDA   
   positive negative n    positive negative n
ELISA positive 24 3 27 ELISA positive 21 16 37
  negative 7 195 202   negative 14 178 192
  n 31 198 229   n 35 194 229
  1. Investigating 85 APS patients, 65 DC patients, and 79 NHS in ELISA and MDLA, no statistical difference could be detected for both techniques. According to the McNemar test, differences for anti-CL IgG (1.75%, 95% CI: -2.97% to 6.05%), anti-CL IgM (3.93%, 95% CI: -1.25% to 8.33%), anti-β2 GPI IgG (1.75%, 95 CI: -1.33% to 3.78%), and anti- β2 GPI IgM (0.87%, 95% CI: -4.11% to 5.67%) were not significant (P = 0.5563, P = 0.1508, P = 0.3438, and P = 0.1508, respectively). anti-β2 GPI, anti-beta2-glycoprotein I;
  2. anti-CL, anti-cardiolipin; ELISA, enzyme-linked immunosorbent immunoassay; MLDA, multi-line dot assay.